general transcription factor / transcription factor (2024)

FAQs

What are general transcription factors in transcription? ›

General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (promoter) on DNA to activate transcription of genetic information from DNA to messenger RNA.

The preinitiation complex normally contains RNA polymerase II and six general transcription factors – TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH.

There are different technologies available to analyze transcription factors. On the genomic level, DNA-sequencing and database research are commonly used. The protein version of the transcription factor is detectable by using specific antibodies. The sample is detected on a western blot.

Transcription Factors. The proteins that bind to DNA regulatory elements (promoter, enhancer) to activate or repress transcription.

The four transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) together can convert human fibroblasts to induced pluripotent stem cells (iPSCs).

Five general transcription factors are required for initiation of transcription by RNA polymerase II in reconstituted in vitro systems (Figure 6.12).

The human genome contains ∼2000 transcriptional regulatory proteins, including ∼1600 DNA-binding transcription factors (TFs) recognizing characteristic sequence motifs to exert regulatory effects on gene expression.

(tran-SKRIP-shun FAK-ter) One of a group of proteins that play an important role in controlling the activity of genes. Transcription factors help control when and how genes are turned on or off in a cell by binding to nearby DNA and to other DNA-associated proteins.

On this basis, Mediator is identified as a general transcription factor, comparable in importance to RNA polymerase II and other general factors for the initiation of transcription. The possibility that Mediator serves as an anti-inhibitor, opposing the effects of global negative regulators, is largely excluded.

Transcription factors find the genes for the proteins the cell needs to make and bind to the promoters so RNA polymerase can attach and copy the gene. Many promoters contain a particular sequence called the TATA box because it contains alternating T and A nucleotides.

Do you need transcription factors for transcription? ›

They are part of the cell's core transcription toolkit, needed for the transcription of any gene. However, many transcription factors (including some of the coolest ones!) are not the general kind. Instead, there is a large class of transcription factors that control the expression of specific, individual genes.

The role of the general transcription factors is to bind to the promoter region of the gene and facilitate the binding of the RNA polymerase enzyme that catalyzes DNA transcription.

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.

Transcription factors are proteins that regulate transcription by binding to specific DNA sequences and either promoting or inhibiting the process. They contain DNA-binding and regulatory domains, and their activity can be influenced by various factors, ultimately impacting gene expression.

Transcription factors (TFs) are regulatory proteins whose function is to activate (or more rarely, to inhibit) transcription of DNA by binding to specific DNA sequences. TFs have defined DNA-binding domains with up to 10⁶-fold higher affinity for their target sequences than for the remainder of the DNA strand.

Transcription factors consist of two essential functional domains: a DNA-binding domain and an activator domain. The DNA-binding domain consists of amino acids that recognize specific DNA bases near the start of transcription.

General transcription factors only regulate the housekeeping genes while regulatory transcription factors control all of the other genes.

Expert-Verified Answer. The primary function of transcription factors is to control gene expression.