Summary
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- Official Symbol
- Myf5provided by MGI
- Official Full Name
- myogenic factor 5provided by MGI
- Primary source
- MGI:MGI:97252
- See related
- Ensembl:ENSMUSG00000000435 AllianceGenome:MGI:97252
- Gene type
- protein coding
- RefSeq status
- VALIDATED
- Organism
- Mus musculus
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
- Also known as
- Myf-5; bHLHc2; B130010J22Rik
- Summary
- Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; regulation of cell-matrix adhesion; and somitogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and skeletal musculature. Orthologous to human MYF5 (myogenic factor 5). [provided by Alliance of Genome Resources, Apr 2022]
- Expression
- Biased expression in limb E14.5 (RPKM 2.7), ovary adult (RPKM 0.6) and 1 other tissue See more
- Orthologs
- human all
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Genomic context
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- Location:
- 10 D1; 10 55.95 cM
- Exon count:
- 4
Annotation release | Status | Assembly | Chr | Location |
---|---|---|---|---|
RS_2024_02 | current | GRCm39 (GCF_000001635.27) | 10 | NC_000076.7 (107318769..107322787, complement) |
108.20200622 | previous assembly | GRCm38.p6 (GCF_000001635.26) | 10 | NC_000076.6 (107482908..107486927, complement) |
Chromosome 10 - NC_000076.7
Genomic regions, transcripts, and products
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Expression
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- Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
- Description: RNA profiling data sets generated by the Mouse ENCODE project.
- BioProject: PRJNA66167
- Publication: PMID 25409824
- Analysis date: n/a
Bibliography
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Related articles in PubMed
- Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Kan L, et al. Stem Cells, 2009 Jan. PMID 18832590, Free PMC Article
- The myogenic factor Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification. Ustanina S, et al. Stem Cells, 2007 Aug. PMID 17495111
- Control of Myf5 activation in adult skeletal myonuclei requires ERK signalling. Perez-Ruiz A, et al. Cell Signal, 2007 Aug. PMID 17481856
- A homeo-paired domain-binding motif directs Myf5 expression in progenitor cells of limb muscle. Buchberger A, et al. Development, 2007 Mar. PMID 17301086
- Muscle satellite cells and endothelial cells: close neighbors and privileged partners. Christov C, et al. Mol Biol Cell, 2007 Apr. PMID 17287398, Free PMC Article
GeneRIFs: Gene References Into Functions
- A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.
Title: A dual-color PAX7 and MYF5 invivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.
- Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Title: Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
- PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
Title: PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
- MLL1 facilitates proliferation of myoblasts and Pax7-positive satellite cells by epigenetically regulating Myf5.
Title: MLL1 promotes myogenesis by epigenetically regulating Myf5.
- The induction phase of primary Myf5+ brown adipogenesis.
Title: STAT3 suppresses Wnt/β-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis.
- Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7.
Title: The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
- An absolute requirement for either MyoD or Myf5 in muscle regeneration.
Title: Loss of MyoD and Myf5 in Skeletal Muscle Stem Cells Results in Altered Myogenic Programming and Failed Regeneration.
- Novel RNA-binding activity of MYF5 enhances Ccnd1 mRNA translation during myogenesis.
Title: Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.
- Transcription of the skeletal muscle program is achieved by the expression of MyoD, which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites
Title: Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation.
- The Myf5- and Myogenin-deficient mice showed a partial or complete, respectively, loss of TMC in an otherwise regularly structured thymus.
Title: Myf5 and Myogenin in the development of thymic myoid cells - Implications for a murine in vivo model of myasthenia gravis.
Variation
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Pathways from PubChem
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Interactions
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Products | Interactant | Other Gene | Complex | Source | Pubs | Description |
---|
General gene information
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Markers
- PMC15073P2 (e-PCR)
- Myf5 (e-PCR), detects polymorphism
- NoName (e-PCR)
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- NoName (e-PCR)
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
- Myf5 (e-PCR), detects polymorphism
Gene Ontology Provided by MGI
Function | Evidence Code | Pubs |
---|---|---|
enables DNA binding | IEA Inferred from Electronic Annotation | |
enables DNA-binding transcription activator activity, RNA polymerase II-specific | IDA Inferred from Direct Assay | PubMed |
enables DNA-binding transcription factor activity, RNA polymerase II-specific | IBA Inferred from Biological aspect of Ancestor | |
enables DNA-binding transcription factor activity, RNA polymerase II-specific | TAS Traceable Author Statement | PubMed |
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA Inferred from Biological aspect of Ancestor | |
enables protein dimerization activity | IEA Inferred from Electronic Annotation | |
enables sequence-specific DNA binding | IDA Inferred from Direct Assay | PubMed |
Component | Evidence Code | Pubs |
---|---|---|
located_in nucleoplasm | ISO Inferred from Sequence Orthology | |
located_in nucleus | TAS Traceable Author Statement | PubMed |
General protein information
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- Preferred Names
- myogenic factor 5
- Names
- myogenic regulatory factor MYF-5
NCBI Reference Sequences (RefSeq)
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RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_008656.5 → NP_032682.1 myogenic factor 5
See identical proteins and their annotated locations for NP_032682.1
Status: VALIDATED
- Source sequence(s)
- AK044894, AK083402
- Consensus CDS
- CCDS24161.1
- UniProtKB/Swiss-Prot
- P24699, Q543W7
- UniProtKB/TrEMBL
- A2RSK4
- Related
- ENSMUSP00000000445.2, ENSMUST00000000445.2
- Conserved Domains (3) summary
-
- smart00520
Location:1 → 88 - BASIC; Basic domain in HLH proteins of MYOD family
- pfam12232
Location:143 → 214 - Myf5; Myogenic determination factor 5
- cd18937
Location:83 → 146 - bHLH_TS_Myf5; basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins
- smart00520
RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference GRCm39 C57BL/6J
Genomic
-
NC_000076.7Reference GRCm39 C57BL/6J
- Range
- 107318769..107322787 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006513319.3 → XP_006513382.1 myogenic factor 5 isoform X1
See identical proteins and their annotated locations for XP_006513382.1
- UniProtKB/Swiss-Prot
- P24699, Q543W7
- UniProtKB/TrEMBL
- A2RSK4
- Conserved Domains (3) summary
-
- smart00520
Location:1 → 88 - BASIC; Basic domain in HLH proteins of MYOD family
- pfam12232
Location:143 → 214 - Myf5; Myogenic determination factor 5
- cd18937
Location:83 → 146 - bHLH_TS_Myf5; basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins
- smart00520
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Nucleotide | Protein | Strain | |
---|---|---|---|
Heading | Accession and Version |
Protein Accession | Links | |
---|---|---|
GenPept Link | UniProtKB Link | |
P24699.1 | GenPept | UniProtKB/Swiss-Prot:P24699 |
Additional links
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Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
- Dryad Digital Repository
- Interologous Interaction Database
- MilliporeSigma
- Bgee database
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- Eukaryotic Promoter Database
- GlyGen glycoinformatics resource
- Ingenuity Pathways Analysis
- InnateDB
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PANTHER Classification System
- PhosphoSitePlus
- Addgene Non-profit plasmid repository
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- OriGene