Combined factor V (5) and factor VIII (8) deficiency is a very rare inherited bleeding disorder. It is completely separate from factor V deficiency and factor VIII deficiency. Factor V (FV) and factor VIII (FVIII) are proteins in the blood which help blood clot. In this disorder, levels of both factors are much lower than normal. Usually both parents must carry the gene alteration causing the disorder to pass it on to their child and for their child to have the disorder.
Links to selected resources:
What Is Combined Factor V and Factor VIII Deficiency?
(World Federation of Hemophilia)
Explains the causes of this blood disorder, its symptoms, diagnosis and treatment.
Combined factor V and factor VIII deficiency
(Canadian Hemophilia Society)
Explains what combined factor V and factor VIII deficiency is, how common it is, how it is passed on, symptoms, diagnosis and treatment.
Source:What are rare clotting factor deficiencies? World Federation of Hemophilia, Montreal, Canada, 2023.
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