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- Summary
Hydrogen peroxide is a compound used as a disinfectant and sterilizer.
- Brand Names
Eskata, Orajel Mouth Sore Rinse
- Generic Name
- Hydrogen peroxide
- DrugBank Accession Number
- DB11091
- Background
Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition. Hydrogen peroxide is formed in the body of mammals during reduction of oxygen either directly in a two-electron transfer reaction 4. As a natural product of metabolism, it readily undergoes decomposition by catalase in normal cells 4.
Due to its potent and broad-spectrum antimicrobial actions, hydrogen peroxide is used in both liquid and gas form for preservative, disinfection and sterilization applications as an oxidative biocide 1. It is used in industrial and cosmetic applications as a bleaching agent. Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA 4; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg whites, and dried egg yolks.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
- Weight
- Average: 34.0147
Monoisotopic: 34.005479308 - Chemical Formula
- H2O2
- Synonyms
- Hydrogen peroxide
- External IDs
- A-101
- NSC-19892
Pharmacology
- Indication
Indicated to be used as a disinfectant and sterilizer.
See AlsoJumping Worms – Invasive Species CentreWound Myiasis Management: What Works, What Doesn’t — BROWN EMERGENCY MEDICINE BLOGDoes insect control using Hydrogen peroxide work?How To Use Hydrogen Peroxide For Nail Fungus: A Step-By-Step GuideReduce drug development failure rates
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- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Ear infection bacterial ••• ••• •••••••• • ••••• Treatment of Seborrheic keratosis (sk) •••••••••••• •••••••• Treatment of Excess ear wax ••• ••• •••••••• • ••••• Treatment of Superficial skin infections ••• ••• ••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Hydrogen peroxide exhibits antimicrobial properties against most forms of microorganisms, including dormant forms with known high resistance profiles, such as bacterial spores and protozoal cysts. It acts as an oxidative biocide to generate free radical species to induce DNA, protein and membrane lipid damage via oxidation.
- Mechanism of action
The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids in vivo 2. The oxidizing radical as the ferryl radical induces DNA oxidation 2.
Target Actions Organism ATyrosine-protein phosphatase non-receptor type 1 inhibitor
Humans - Absorption
It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue 4.
- Volume of distribution
Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney 4.
- Protein binding
Not Available
- Metabolism
Hydrogen peroxide is reduced by glutathione peroxidase, which is an endogenous enzyme in human tissue. It is rapidly decomposed to oxygen and water when in contact with catalase, an enzyme found in blood and most tissues 4.
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- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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- Toxicity
Oral LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig. LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours MSDS.
Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans. Inhalation of highly concentrated vapours causes extreme irritation of nose and throat 4.
Hydrogen peroxide has no known carcinogenic potential. It was shown to be mutagenic to bacteria (Salmonella typhimurium) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli 4. It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro 4.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
- Approved
- Vet approved
- Nutraceutical
- Illicit
- Withdrawn
- Investigational
- Experimental
- All Drugs
Drug Interaction Integrate drug-drug
interactions in your softwareAcetylcysteine The therapeutic efficacy of Acetylcysteine can be decreased when used in combination with Hydrogen peroxide. Albutrepenonacog alfa Hydrogen peroxide may increase the thrombogenic activities of Albutrepenonacog alfa. Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Hydrogen peroxide. Alteplase The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Alteplase. Aminocaproic acid Aminocaproic acid may increase the thrombogenic activities of Hydrogen peroxide. - Food Interactions
- No interactions found.
Products
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- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Eskata Solution 40 mg/100mg Topical Aclaris Therapeutics, Inc. 2017-12-14 Not applicable Eskata Solution 40 mg/100mg Topical Aclaris Therapeutics, Inc. 2017-12-14 Not applicable Perioselect Hydrogen Peroxide Solution 1.7% Liquid 1.7 % Dental Sultan Healthcare 1992-12-31 1996-09-06 Preop Rinse Liquid 3.8 mL/100mL Oral Everbrands, Inc. dba EverPure, Inc. 2020-12-30 Not applicable - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 100 toothpast e Afternoon Gel, dentifrice 2.14 g/100g Oral MGRU 2020-12-01 Not applicable 16oz Hydorgen Peroxide Liquid 3 mL/1 Topical Ningbo Liyuan Daily Chemical Products Co., Ltd. 2017-01-04 Not applicable 16oz Hydrogen Peroxide Liquid 3 mL/3mL Oral; Topical Collective Science Integration 2020-09-24 Not applicable 3 Hydrogen Peroxide Liquid 30 mg/1mL Topical Jell Pharmaceuticals Pvt Ltd. 2021-01-10 Not applicable 3 percent Hydrogen Peroxide Gel 3 mL/100mL Topical Solugen Blending, LLC 2020-10-12 Not applicable - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4234 First Aid Kit Hydrogen peroxide (3 mL/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) Kit Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable Antiseptic Mouth Sore Hydrogen peroxide (15 mg/1mL) + Menthol (1 mg/1mL) Rinse Periodontal CVS PHARMACY 2021-06-18 Not applicable BANEN Rinse-free Hand Sanitizer (II) Hydrogen peroxide (0.5 mL/500mL) + Ethanol (400 mL/500mL) Liquid Extracorporeal LIONSER Medical Disinfectant(Hangzhou) Co., Ltd. 2020-03-24 Not applicable Defense AG Disinfectant Hydrogen peroxide (0.125 mL/100mL) + Isopropyl alcohol (75 mL/100mL) Spray Topical Nexderma 2020-11-09 Not applicable Defense AG Disinfectant Hydrogen peroxide (0.125 mL/100mL) + Ethanol (80 mL/100mL) Spray Topical Nexderma 2020-11-09 Not applicable - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 100 toothpast e Afternoon Hydrogen peroxide (2.14 g/100g) Gel, dentifrice Oral MGRU 2020-12-01 Not applicable 4234 First Aid Kit Hydrogen peroxide (3 mL/100mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) Kit Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable Dio Whitening Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Dio 2015-01-22 Not applicable Dr.EL TOOTH WHITE TOOTH Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Dental Dr. EL CO., LTD. 2019-08-01 Not applicable Dr.LORD Propol Whitening Tooth Hydrogen peroxide (2.14 g/100g) + Silicon dioxide (7.0 g/100g) + alpha-Tocopherol acetate (0.2 g/100g) Paste, dentifrice Oral Red 99 2022-03-01 Not applicable
Categories
- ATC Codes
- D08AX01 — Hydrogen peroxide
- D08AX — Other antiseptics and disinfectants
- D08A — ANTISEPTICS AND DISINFECTANTS
- D08 — ANTISEPTICS AND DISINFECTANTS
- D — DERMATOLOGICALS
- D11AX — Other dermatologicals
- D11A — OTHER DERMATOLOGICAL PREPARATIONS
- D11 — OTHER DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- Drug Categories
- Alimentary Tract and Metabolism
- Anions
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antifibrinolytic Agents
- Antiinfectives and Antiseptics for Local Oral Treatment
- Antiseptics and Disinfectants
- Compounds used in a research, industrial, or household setting
- Dermatologicals
- Electrolytes
- Free Radicals
- Ions
- Noxae
- Otologicals
- Oxidants
- Oxides
- Oxygen Compounds
- Peroxides
- Reactive Oxygen Species
- Sensory Organs
- Stomatological Preparations
- Toxic Actions
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as hom*ogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
- Kingdom
- Inorganic compounds
- Super Class
- hom*ogeneous non-metal compounds
- Class
- hom*ogeneous other non-metal compounds
- Sub Class
- Not Available
- Direct Parent
- hom*ogeneous other non-metal compounds
- Alternative Parents
- Not Available
- Substituents
- hom*ogeneous other non metal
- Molecular Framework
- Not Available
- External Descriptors
- reactive oxygen species, inorganic peroxide (CHEBI:16240) / a small molecule (HYDROGEN-PEROXIDE)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- BBX060AN9V
- CAS number
- 7722-84-1
- InChI Key
- MHAJPDPJQMAIIY-UHFFFAOYSA-N
- InChI
InChI=1S/H2O2/c1-2/h1-2H
- IUPAC Name
peroxol
- SMILES
OO
References
- General References
- Finnegan M, Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms. J Antimicrob Chemother. 2010 Oct;65(10):2108-15. doi: 10.1093/jac/dkq308. Epub 2010 Aug 16. [Article]
- Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action. J Antimicrob Chemother. 2012 Jul;67(7):1589-96. doi: 10.1093/jac/dks129. Epub 2012 Apr 24. [Article]
- HYDROGEN PEROXIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- Chemical Summary for Hydrogen Peroxide - SSWM [Link]
- FDA Approved Drug Products: Eskata Hydrogen Peroxide Topical Solution (Discontinued) [Link]
- External Links
- Human Metabolome Database
- HMDB0003125
- KEGG Compound
- C00027
- PubChem Compound
- 784
- PubChem Substance
- 347827892
- ChemSpider
- 763
- RxNav
- 5499
- ChEBI
- 16240
- ChEMBL
- CHEMBL71595
- PDBe Ligand
- PEO
- Wikipedia
- Hydrogen_peroxide
- PDB Entries
- 1ao2 / 1ao4 / 1asp / 1d6z / 1g5l / 1ggf / 1gj2 / 1h57 / 1h5f / 1h5g … show 92 more
- MSDS
Download (53.8 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
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View sample dataNot Available Completed Basic Science Normal Contact Lens Wear 1 somestatus stop reason just information to hide Not Available Completed Other Coronavirus Disease 2019 (COVID‑19) / Infections, Coronavirus 1 somestatus stop reason just information to hide Not Available Completed Prevention Coronavirus Disease 2019 (COVID‑19) 1 somestatus stop reason just information to hide Not Available Completed Prevention Postoperative pain 1 somestatus stop reason just information to hide Not Available Completed Supportive Care Gingivitis 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
Not Available
- Packagers
Not Available
- Dosage Forms
Form Route Strength Gel, dentifrice Oral 2.14 g/100g Liquid Topical 3 mL/1 Liquid Oral; Topical 3 mL/3mL Gel Topical 3 mL/100mL Spray Topical 3 g/100mL Kit Respiratory (inhalation); Topical Solution Topical 6 g Solution Topical 7.2 g Solution Topical 6.01 g Spray Topical 30 mL/1000mL Rinse Periodontal Mouthwash Oral 150 mg/100L Spray Topical 3.0 mL/100mL Liquid Extracorporeal Spray Topical 1 mL/100mL Liquid Topical 0.085 mL/70mL Liquid Topical 2.65 mL/100mL Cream Topical Spray Topical Rinse Topical 15 mg/1mL Paste, dentifrice Dental Solution Topical 3.6 g Liquid Topical 5 mg/100mL Liquid Topical 3 mL/100mL Liquid Topical 3 g/100mL Liquid Topical 4 mL/100mL Liquid Topical 13.5 mL/450mL Cloth Topical Paste, dentifrice Topical Gel Dental 8.57 g/100mL Solution Topical 40 mg/100mg Liquid Oral 1.5 g/100mL Spray, metered Topical 3.54 mL/119mL Aerosol, spray Topical Cream Topical 1.5 % Liquid Dental; Oral; Topical 0.03 mL/100mL Liquid Oral 0.015 mg/1mL Liquid Oral; Topical 2.65 mL/100mL Liquid Oral; Topical 3 mL/100mL Liquid Topical .3 kg/100L Liquid Topical 0.03 L/0.03L Liquid Topical 0.3 mL/1mL Liquid Topical 3 mg/1mL Liquid Topical 30 mL/1L Liquid Topical 50 mL/100mL Liquid Topical 8.57 g/100mL Lotion Topical 3 kg/100L Solution Oral; Topical 2.65 mL/100mL Solution Oral; Topical 3 mL/100mL Solution Topical .3 kg/100L Solution Topical 0.03 mL/1mL Solution Topical 3 mL/100mL Solution Topical 3 mg/100mL Solution Topical 30 mg/1mL Spray Topical 3.57 mL/118mL Spray Topical 30 mg/1mL Spray Topical 30 mL/1L Liquid Topical 6 g / 100 mL Swab Topical 0.03 mL/1 Liquid Topical 6 mL / 100 mL Liquid Topical 6 % Liquid Oral 1.5 1/1001 Liquid Topical 3 % Solution 20 ml/100ml Solution Topical 3 g / 100 mL Solution Topical 3 % Solution Topical 6 % w/v Solution Topical Kit Oral Kit Oral 0.015 mg/1mL Paste Dental Gel Topical 2.8 g/100g Liquid Topical 30 mg/1mL Liquid Topical Spray Topical 43.275 g/1L Mouthwash Dental 15 mg/1mL Liquid Oral 15 mg/1mL Cloth Topical 1.22 mg/100mg Spray Topical 0.48 g/40mL Liquid Extracorporeal 15 mg/500mL Liquid Oral Liquid Oral 0.015 mL/1mL Mouthwash Oral 1.5 % Solution Buccal Rinse Oral 0.03 mL/20mL Solution Oral 2.94 mL/2.94mL Spray Oral 2.94 mL/2.94mL Solution Oral 1.5 mL/1.5mL Spray Oral 1.5 mL/1.5mL Liquid Buccal 15 mg/1mL Gel Dental; Periodontal 17 g/100mL Gel Dental; Periodontal 1.7 g/100g Gel Topical 17 mg/1g Gel Dental 17 mg/1g Liquid Dental 1.7 % Mouthwash Buccal 15 mg/1mL Rinse Oral 1.5 mL/100mL Rinse Buccal 15 mg/1mL Cloth Topical 30 mg/1mL Liquid Topical 3 g/100g Liquid Topical 3 mL/1mL Swab Topical 30 mg/1mL Gel, dentifrice Dental 35 mL/100mL Rinse Oral 26.5 mg/1mL Liquid Oral 3.8 mL/100mL Liquid Topical 0.03 mL/1mL Spray Topical 0.03 mL/1mL Liquid Topical 1.5 g/100mL Liquid Topical 14.19 mL/473mL Gel Oral 3 g/100g Kit Dental Kit; mouthwash Buccal 15 mg/1mL Kit Buccal Gel Topical Rinse Oral Kit Topical Liquid Topical 5.845 g/100mL Concentrate Topical 18 mL/100mL Cloth Topical 3 mL/100mL Swab Buccal 15 mg/1mL Cloth Topical 0.03 mL/1mL Spray Topical 3 mL/100mL Mouthwash Topical 15 mg/1mL Mouthwash Topical 150 mg/10mL Mouthwash Topical 1588 mg/1mL Kit Buccal 15 mg/1mL Solution Buccal 15 mg/1mL Rinse Dental 0.15 mL/100mL Paste, dentifrice Dental 2.14 g/100g Kit Buccal 15 [iU]/1mL Cloth Topical 0.6684 g/44.56g Solution 6 % w/v Paste, dentifrice Oral Paste, dentifrice Oral 1.92 g/90g Liquid Oral 1.5 % Solution Topical Liquid Oral 0.42 g/15g Liquid Oral 2.8 g/100g Solution Topical 6 % Spray, metered Topical 3.57 mL/119mL Cloth Topical 3 g/1001 - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US7381427 No 2008-06-03 2022-06-08 US9675639 No 2017-06-13 2035-07-04 US9980983 No 2018-05-29 2035-04-21 US10098910 No 2018-10-16 2035-04-21 US10493103 No 2019-12-03 2035-04-21 US10729720 No 2020-08-04 2035-04-21
Properties
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) -33 MSDS boiling point (°C) 108 MSDS water solubility Soluble in cold water MSDS - Predicted Properties
Property Value Source logP -0.45 Chemaxon pKa (Strongest Acidic) 11.52 Chemaxon pKa (Strongest Basic) -4.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 40.46 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 5.13 m3·mol-1 Chemaxon Polarizability 2.29 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-001i-9000000000-4749d46780bc552fb9af Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9000000000-86b45185e1deeaca15e1 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-9000000000-d77c0031598ec85f7286 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9000000000-86b45185e1deeaca15e1 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-9000000000-d77c0031598ec85f7286 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-9000000000-86b45185e1deeaca15e1 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-9000000000-d77c0031598ec85f7286 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 107.74653 predicted
DeepCCS 1.0 (2019) [M+H]+ 109.47837 predicted
DeepCCS 1.0 (2019) [M+Na]+ 116.212265 predicted
DeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
Yes
- Actions
Inhibitor
- General Function
- Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET
- Specific Function
- Cadherin binding
- Gene Name
- PTPN1
- Uniprot ID
- P18031
- Uniprot Name
- Tyrosine-protein phosphatase non-receptor type 1
- Molecular Weight
- 49966.44 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
Unknown
- Actions
Substrate
- General Function
- Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402)
- Specific Function
- Glutathione peroxidase activity
- Gene Name
- GPX1
- Uniprot ID
- P07203
- Uniprot Name
- Glutathione peroxidase 1
- Molecular Weight
- 22087.94 Da
References
- Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN: Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9. [Article]
- HYDROGEN PEROXIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- Chemical Summary for Hydrogen Peroxide - SSWM [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
Unknown
- Actions
Substrate
- General Function
- Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)
- Specific Function
- Aminoacylase activity
- Gene Name
- CAT
- Uniprot ID
- P04040
- Uniprot Name
- Catalase
- Molecular Weight
- 59755.82 Da
References
- Gaetani GF, Galiano S, Canepa L, Ferraris AM, Kirkman HN: Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9. [Article]
- HYDROGEN PEROXIDE - National Library of Medicine HSDB ... - Toxnet [Link]
- Chemical Summary for Hydrogen Peroxide - SSWM [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
Unknown
- Actions
Inhibitor
- General Function
- Alkaline phosphatase that can hydrolyze various phosphate compounds
- Specific Function
- Alkaline phosphatase activity
- Gene Name
- ALPG
- Uniprot ID
- P10696
- Uniprot Name
- Alkaline phosphatase, germ cell type
- Molecular Weight
- 57376.515 Da
References
- Finnegan M, Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms. J Antimicrob Chemother. 2010 Oct;65(10):2108-15. doi: 10.1093/jac/dkq308. Epub 2010 Aug 16. [Article]
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