Malignant Hyperthermia (MH Dog) | generatio.de (2024)

• High fever
• Muscle cramps/stiffness
• Breathing difficulties

• Malignant hyperthermia (MH) is also known as "Canine Stress Syndrome" (CSS).
• Some affected animals appear to be healthy but exhibit the above symptoms under stress.
• The application of narcotics and muscle relaxants promote the occurrence of MH, so it is essential to test for MH before medical treatment or surgery.

This mutation test detects a change in a single base pair (c.1640T>C) in exon 15 of the RYR1 gene.

Test in Shop

Also in the:

• Doberman 1 package
• Labrador Retriever B package (DRC P3)

Inheritance: autosomal-dominant

→ The disease occurs when one or both copies of the gene (n/MH or MH/MH) are affected by the mutation.

Genotypes:

n/n = normal

The dog has no variants for MH and therefore cannot pass it on to offspring.

n/MH = affected (heterozygous)

The mutation is passed on to 50% of the offspring. These 50% are also affected.

MH/MH = affected (hom*ozygous)

100% of the mutation is passed on to the offspring. All offspring are also affected.

Roberts, M.C., Mickelson, J.R., Patterson, E.E., Nelson, T.E., Armstrong, P.J., Brunson, D.B., Hogan, K.: Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene encoding the skeletal muscle calcium release channel (RYR1). Anesthesiology 95:716-725, 2001. Pubmed reference: 11575546.

Further informationis available at: Online Mendelian Inheritance in Animals.